Broncos vs. Bills Opening Line: Denver is the Home Underdog

broncos bills opening line
Oct 27, 2019; Orchard Park, NY, USA; Buffalo Bills quarterback Josh Allen (17) drops back to pass against the Philadelphia Eagles during the second quarter at New Era Field. Mandatory Credit: Rich Barnes-USA TODAY Sports

Believe it or not, the Broncos have a legitimate shot at finishing the season with a .500 record, but the Bills are the biggest obstacle standing in their way. The Denver Broncos are going to be home underdogs against the Buffalo Bills in Week 15.

The Broncos vs. Bills line opens with Denver at +5.5 on the spread line and +200 on the moneyline. The total is set to 48.5 points.


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Here are the current Broncos vs. Bills odds. These are the odds at DraftKings Sportsbook and most Colorado online sportsbooks have similar odds as of September 18, 2021 1:57 AM.

Let’s take a look at the line, spread, total, and odds for this Week 15 matchup between the Broncos and Bills.

Team Spread Moneyline Total
Buffalo Bills -5.5 (-107) -250 O 48.5 (-105)
Denver Broncos +5.5 (-114) +200 U 48.5 (-115)



The spread on the Broncos is +5.5 at DraftKings Sportsbook Colorado.

The Broncos are significant underdogs coming into this game. It’s no surprise when you look at what the Bills are doing right now. Buffalo just handled the Pittsburgh Steelers to extend their winning streak to three games.

With that said, the Broncos looked good against the Carolina Panthers in Week 14. This will be the 14th time that the Broncos are underdogs this year. Both teams are 8-5 against the spread on DraftKings Sportsbook this season.

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The Broncos are +200 on the moneyline entering Week 15. Meanwhile, the Bills are -250.

Do you think the Broncos are going to be able to pull off the upset at home this week? If you do, there is good value on the moneyline. Denver is only 2-4 at Mile High Stadium this year with those wins coming against the Los Angeles Chargers and the Miami Dolphins.

If you are looking at taking the Buffalo moneyline, it might be wise to include that one in a parlay. Bettors will have to lay down a lot of money to net any kind of significant return on Bills -250 as a standalone play.


The Broncos vs. Bills over/under is set at 48.5 points.

The total is in an interesting place. On one hand, the Bills have gone over on the total points in nine of their 13 games this season. However, the Broncos have scored more than 20 points just once at home this season.

Drew Lock’s Week 14 performance should give over bettors some confidence. The second-year quarterback put together his best performance as a pro, throwing for 280 yards, four touchdowns, and no interceptions. If Lock can replicate that performance against the Bills, the over is looking like a lock (pun intended).

Broncos vs. Bills Props For Week 15

Everyone loves to bet straight up against the spread and the total, but player props are among some of the most profitable ways to bet. Week in and week out, there are tons of player props for bettors to play. Although player prop markets won’t hit the board until Thursday or Friday, here are some of our favorites.

  • Total passing yards
  • Total rushing yards
  • Total receiving yards
  • Player vs. Player matchups
  • Player to score a touchdown (first/last/anytime)